Conjugation of lipophilic albumin-binding moiety to RNA for improved carrier-free in vivo pharmacokinetics and gene silencing

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United States of America Patent

PATENT NO 11147827
APP PUB NO 20180064749A1
SERIAL NO

15671131

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Abstract

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Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes administering a compound comprising a RNA directly conjugated to an albumin-binding group to a subject in need thereof.

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Patent Owner(s)

  • VANDERBILT UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Duvall, Craig L Nashville, US 28 215
Sarett, Samantha M Nashville, US 3 1
Werfel, Thomas A Nashville, US 3 1

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