Rapid and efficient bioorthogonal ligation reaction and boron-containing heterocycles useful in conjunction therewith

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United States of America Patent

PATENT NO 10435418
APP PUB NO 20180065993A1
SERIAL NO

15700911

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Abstract

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A reaction method comprising combining a carbonyl-substituted arylboronic acid or ester and an α-effect amine in aqueous solution at a temperature between about −5 C to 55 C, and a pH between 2 and 8 to produce an adduct. A process is also provided comprising: contacting a boron compound having a boron atom bonded to a sp2 hybridized carbon conjugated with a cis-carbonyl, the boron having at least one labile substituent, with an α-effect amine, in a solvent for a time sufficient to form an adduct, which may proceed to further products.

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  • THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY O

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dilek, Ozlem Istanbul, TR 2 5
Mukherjee, Kamalika Binghamton, US 4 5
Tuttle, Susan Bane Vestal, US 4 5

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