ACETYLATED PCSK9
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United States of America Patent
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Feb 17, 2016
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Feb 18, 2015
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Abstract
The invention relates to antibodies reactive to acetylated PCSK9, particularly to PCSK9 acetylated in position Lys421, Lys273, Lys69, Lys83, Lys243, Lys258, Lys494, and/or Lys506, and related reagents. The invention also relates to a method of reducing LDL-cholesterol level in a patient in need thereof, said method comprising administering to the subject an effective amount of an antibody binding to acetylated PCSK9. The invention also relates to a method of treating a cholesterol related disorder in a patient in need thereof, said method comprising administering to the subject an effective amount of an antibody binding to acetylated PCSK9. The invention also relates to a method of treating hypercholesterolemia in a patient in need thereof, said method comprising administering to the subject an effective amount of an antibody binding to acetylated PCSK9.
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