Methods for labeling and manipulating a cellular circuit

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United States of America Patent

PATENT NO 10619155
APP PUB NO 20180066249A1
SERIAL NO

15558900

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Abstract

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The invention relates to methods and kits for labeling and manipulating a cellular circuit. The methods includes transfecting a first-order cell in the cellular circuit with a nucleic acid molecule encoding a tethered ligand, and a second-order cell in the cellular circuit with a nucleic acid molecule encoding a receptor and an effector fusion polypeptide, a nucleic acid molecule encoding a receptor interactor and protease fusion polypeptide, and a nucleic acid molecule encoding a reporter/modifier gene.

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Patent Owner(s)

Patent OwnerAddress
BROWN UNIVERSITY69 BROWN STREET BOX 1822 PROVIDENCE RI 02912

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barnea, Gilad Providence, US 6 46
Fisher, John Providence, US 84 3224
Johnson, Mark Boston, US 366 9317
Richman, Ethan Sharon, US 1 0
Snell, Nathaniel Providence, US 1 0
Szymanski, John New York, US 7 79
Talay, Mustafa Providence, US 1 0

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