Blood brain barrier models and methods to generate and use the same

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United States of America Patent

PATENT NO 10877026
APP PUB NO 20180067103A1
SERIAL NO

15697699

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Abstract

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The present disclosure generally relates to a process to prepare a cell culture system that mimics the structure of blood brain barrier (BBB) and are useful to study the functions thereof. In particular, the present invention relates to a direct-contact coculture and triculture systems prepared by plating BMECs on a pre-formed lawn of coculture of astrocytes and pericytes on the apical surface of a culture-chamber to achieve a truly direct contact triculture model for BBB. The cell culture systems disclosed herein are also useful for studying the functions of the blood brain barrier and predicting the efficacy and potential toxicity of a drug candidate.

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Patent Owner(s)

  • PURDUE RESEARCH FOUNDATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Knipp, Gregory T West Lafayette, US 4 3
Kulczar, Christopher D Bremen, US 6 1
Lavan, Monika Lafayette, US 2 1
Lubin, Kelsey E Lafayette, US 3 1
Ngendahimana, Aimable West Lafayette, US 2 1

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