Methods and compositions for CNS delivery of arylsulfatase A

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United States of America Patent

PATENT NO 10646554
APP PUB NO 20180071212A1
SERIAL NO

15684568

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Abstract

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The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an arylsulfatase A (ASA) protein, salt, and a polysorbate surfactant for the treatment of Metachromatic Leukodystrophy Disease.

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Patent Owner(s)

Patent OwnerAddress
TAKEDA PHARMACEUTICAL COMPANY LIMITEDOSAKA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Calias, Pericles Melrose, US 52 750
Campolieto, Paul Charlottesville, US 8 66
Charnas, Lawrence Natick, US 15 101
Pan, Jing Boxborough, US 99 861
Salamat-Miller, Nazila Arlington, US 10 66
Shahrokh, Zahra Weston, US 61 1378
Taylor, Katherine Arlington, US 11 66
Wright, Teresa Leah Lexington, US 16 191

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