Use of single dendritic wedge cell penetrating peptides to facilitate cellular delivery of nanoparticles and nanoparticles carrying cargos

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United States of America Patent

PATENT NO 10183080
APP PUB NO 20180071399A1
SERIAL NO

15694114

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Abstract

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Nanoparticles (and optionally a cargo such as a drug) can be delivered to cells by attaching just a single dendritic peptide to the nanoparticle. The dendritic peptide includes a polyhisitidine motif and a hinge and a spacer connecting the polyhistidine to a lysine-based dendritic wedge displaying at least two copies of a cell-penetrating peptide motif.

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Patent Owner(s)

  • THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Breger, Joyce Greenbelt, US 4 15
Dawson, Philip E San Diego, US 15 218
Delehanty, James B Washington, US 23 75
Medintz, Igor L Springfield, US 38 170
Muttenthaler, Markus Brisbane, AU 2 7

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