Antibody-drug conjugate produced by binding through linker having hydrophilic structure
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United States of America Patent
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Aug 4, 2020
Grant Date -
Mar 15, 2018
app pub date -
Nov 22, 2017
filing date -
Oct 19, 2012
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Abstract
As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula (I) is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- or -L1-L2-LP- wherein the antibody is connected to the terminal of L1, the antitumor compound is connected to the terminal of Lc or LP, and any one or two or more of linkers of L1, L2, and LP has a hydrophilic structure.
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