Active peptide for inhibiting AMPA receptor and preparation method and use thereof

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United States of America Patent

PATENT NO 10800810
APP PUB NO 20180094028A1
SERIAL NO

15834026

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Abstract

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Provided is an active peptide for inhibiting an AMPA receptor and a preparation method and use thereof. The method for preparing the active peptide comprises the following steps: 1) soaking a salmon skin and crushing, adding water and beating, and then adjusting pH to 6.5-7.5; 2) subjecting to a first enzymolysis using a neutral protease; 3) subjecting to a second enzymolysis using papain enzyme and then inactivating enzyme; and 4) centrifuging the enzymatic hydrolysate, and then subjecting the centrifuged supernatant to membrane filtration, concentration and decoloration, to prepare the active peptide. The active peptide contains a tetrapeptide with an amino-acid sequence of Glu-Gly-Ala-Arg. The tetrapeptide has good solubility, can selectively inhibit neuronal synaptic transmission caused by an AMPA receptor, and has a significant antiepileptic effect.

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Patent Owner(s)

  • CHINA NATIONAL RESEARCH INSTITUTE OF FOOD AND FERMENTATION INDUSTRIES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cai, Muyi Beijing, CN 12 1
Chen, Liang Beijing, CN 852 8021
Gu, Huaiyu Beijing, CN 1 0
Lu, Jun Beijing, CN 498 15244
Ma, Yong Beijing, CN 109 7980
Pan, Xingchang Beijing, CN 9 1

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