Mutated rep encoding sequences for use in AAV production

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United States of America Patent

PATENT NO 10400221
APP PUB NO 20180135027A1
SERIAL NO

15862997

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Abstract

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Nucleic acids encoding Parvoviral Rep proteins with a mutated nuclear localization signal (NLS) are provided. Also provided is a nucleic acid comprising a nucleotide sequence encoding a Parvoviral Rep protein with a mutated zinc finger domain and a nucleic acid comprising a nucleotide sequence encoding a Parvoviral Rep protein comprising an amino acid mutation at position 43, 57, 79, 97, 120, 179, 305, 484, 493 or 571 with reference to SEQ ID NO: 2. Nucleic acid constructs and cells, such as insect cells, comprising the nucleic acids are provided as well as a method for producing a recombinant Parvoviral virion using the nucleic acids.

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Patent Owner(s)

  • UNIQURE IP B.V.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bakker, Andrew Christian Amsterdam, NL 23 527
Lubelski, Jacek Amsterdam, NL 12 50
Noordman, Yvet Amsterdam, NL 7 144

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