Methods, systems, and devices for detecting and identifying microorganisms in microbiological culture samples

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United States of America Patent

PATENT NO 10962533
APP PUB NO 20180136204A1
SERIAL NO

15822879

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Abstract

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Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.

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Patent Owner(s)

  • BECTON DICKINSON AND COMPANY

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Carruthers, Erin Gooch Cary, US 2 15
Curry, Adam C Raleigh, US 10 90
Fallows, Eric A Apex, US 9 22
Gorelick, Donald E Nashua, US 4 50
Kessler, Jack Southborough, US 27 346
Kuroda, Melody M H Durham, US 18 138
Lentz, Ammon David York, US 34 664
Lizzi, Michael Justin Stewartstown, US 18 157
Lovette, Spencer Mount Vernon, US 10 75
Ojala, Jeffrey S Candia, US 2 14
Talmer, Mark A Pepperell, US 12 416
Weidemaier, Kristin Raleigh, US 22 825

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