Process for manufacturing 1-cyclopropyl-naphthalenes

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United States of America Patent

PATENT NO 10683245
APP PUB NO 20180186706A1
SERIAL NO

15736420

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Abstract

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A process for preparing 1-cyclopropyl-naphthalene derivatives of Formula (1) wherein R1-R7 are independently hydrogen, alkyl, alkoxy, cycloalkyl or aryl comprising the steps of a) contacting an acid salt of a 1-naphthyl-2-aminoethylketone with a base and a first solvent to obtain a solution wherein the molar ratio of base to 1-naphthyl-2-aminoethylketone acid salt is at least 0.7, b) addition of hydrazine to obtain a 3-(1-naphthyl)-1H-pyrazoline, c) optionally adding a second solvent and/or at least partially removing the first solvent, and d) heating the reaction mixture to a temperature above 190° C. to obtain the compound of Formula (1).

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Patent Owner(s)

Patent OwnerAddress
PATHEON AUSTRIA GMBH & CO KG4020 LINZ

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Giselbrecht, Karl-Heinz Linz, AT 6 16

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