Laser Induced Collagen Crosslinking in Tissue

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United States of America Patent

SERIAL NO

15893096

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Abstract

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The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage or cornea, without using a photosensitizer (e.g., riboflavin), by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of tissue. In an embodiment, the femtosecond laser operates in the infrared frequency range.

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Patent Owner(s)

Patent OwnerAddress
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK412 LOW LIBRARY 535 W 116TH STREET NEW YORK NY 10027

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
TROKEL, Stephen New York, US 8 154
VUKELIC, Sinisa New York, US 13 48

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