Immunostimulating oligonucleotide complex

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United States of America Patent

PATENT NO 10449212
APP PUB NO 20180193371A1
SERIAL NO

15740667

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Abstract

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Provided is an immunostimulating oligonucleotide that is suitable for industrial production and has an excellent type-I IFN inducing activity even when not modified to become a phosphorothioate. This linear double-stranded oligonucleotide contains 10-100 base pairs, wherein the single-stranded oligonucleotides constituting the double-stranded oligonucleotide each contain 2-20 phosphodiester-mediated cytosine-guanine (CpG) sequences, and at least 90% of the internucleotide bonds in each single-stranded oligonucleotide are phosphodiester bonds.

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Patent Owner(s)

  • NATIONAL INSTITUTE FOR MATERIALS SCIENCE; DENKA COMPANY LIMITED

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hanagata, Nobutaka Tsukuba, JP 1 3
Harada, Takafumi Tokyo, JP 14 24
Otsuka, Hiroshi Tokyo, JP 158 1300

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