Compositions and methods for inhibiting gene expression of LPA

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 10662427
APP PUB NO 20180195070A1
SERIAL NO

15901810

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Abstract

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RNA interference (RNAi) agents and RNAi agent conjugates for inhibiting the expression of the LPA (apo(a)) gene are described. Pharmaceutical compositions comprising one or more LPA RNAi agents optionally with one or more additional therapeutics are also described. Delivery of the described LPA RNAi agents to liver cells in vivo provides for inhibition of LPA gene expression and treatment of cardiovascular and cardiovascular-related diseases.

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Patent Owner(s)

  • ARROWHEAD PHARMACEUTICALS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Almeida, Aaron Madison, US 10 22
Almeida, Lauren J Madison, US 21 96
Kanner, Steven Madison, US 8 13
Lewis, David L Madison, US 85 1535
Li, Zhen Monona, US 330 1491
Melquist, Stacey Madison, US 6 12
Pei, Tao Middleton, US 62 169
Rozema, David B Cross Plains, US 101 1882
Trubetskoy, Vladimir S Middleton, US 27 832
Wakefield, Darren H Fitchburg, US 60 949

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