6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of mGluR2 receptors

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United States of America Patent

PATENT NO 10112949
APP PUB NO 20180222908A1
SERIAL NO

15500553

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Abstract

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The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 (“mGluR2”). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mGluR2 subtype of metabotropic receptors is involved.

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Patent Owner(s)

  • JANSSEN PHARMACEUTICA NV

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alonso-de, Diego Sergio Alvar Toledo, ES 1 1
Andrés-Gil, José Ignacio Madrid, ES 34 48
De, Lucas Olivares Ana Isabel Bargas, ES 10 62
Delgado-González, Óscar Santa Cruz de Tenerife, ES 11 16
Trabanco-Suárez, Andrés Avelino Olias del Rey, ES 55 155
Van, Gool Michiel Luc Maria Madrid, ES 37 83

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