Biguanide derivative, a preparation method thereof, and a pharmaceutical composition containing the biguanide derivative as an active ingredient

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United States of America Patent

PATENT NO 10376480
APP PUB NO 20180256520A1
SERIAL NO

15976613

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Abstract

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A biguanide derivative compound with N1-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPKα and inhibition of cancer cell proliferation in a low dose, compared to conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.

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Patent Owner(s)

  • IMMUNOMET THERAPEUTICS, INC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jun, Sung Soo Gyeonggi-do, KR 39 212
Kang, Min Seok Gyeonggi-do, KR 17 83
Kim, Duck Daegu, KR 8 81
Kim, Sung Wuk Gyeonggi-do, KR 50 236
Kim, Yong Eun Daejeon, KR 11 81
Kim, Young Woong Daejeon, KR 19 98
Lee, Ji Sun Daejeon, KR 74 215
Min, Chang Hee Seoul, KR 10 79
Oh, Byung Kyu Daejeon, KR 5 31
Oh, Ju Hoon Gangwon-do, KR 9 78
Park, Se Hwan Daejeon, KR 26 202

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