MICROFLUIDIC METHODS FOR PASSIVE SEPARATION OF CELLS AND PARTICLES

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United States of America Patent

APP PUB NO 20180264473A1
SERIAL NO

15983815

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A method of separating a plurality of particles (14) from a portion of fluid, comprising directing the plurality of particles (14) into a microchannel (12). A first portion (16) of particles (14) is focused into an equilibrium position in the microchannel (12). The focused first portion (16) is directed into a first outlet (18) aligned with the equilibrium position. A portion of the fluid is directed into one or more outlets (20, 22). A microfluidic device (10) for separating a plurality of particles (14) from a portion of fluid, comprising a microchannel (12) having a first aspect ratio and a length L, thereby focusing the particles (14) directed therein into an equilibrium position in the microchannel, wherein at least a first portion (16) of the particles (14) focuses at distance X from a beginning of the microchannel (12). A first outlet (18) disposed after distance X and aligned with the equilibrium position to receive at least the first portion (16) of the particles (14) after the first portion (16) focuses into an equilibrium position in the microchannel (12). At least a second outlet (20) for receiving a second portion of the particles (14) before the second portion focuses into an equilibrium position.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF CINCINNATICINCINNATI OH 45206-0829

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Papautsky, Ian Mason, US 17 253
Zhou, Jian Cincinnati, US 384 3270

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