Assays for screening activity of modulators of members of the hydroxy steroid (17-beta) dehydrogenase (HSD17B) family

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United States of America Patent

PATENT NO 11479802
APP PUB NO 20180291422A1
SERIAL NO

15913366

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Abstract

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Screening methods as well as kits for identifying modulators of hydroxysteroid (17-beta) dehydrogenase (HSD17B) family member proteins, such as HSD17B13, are provided. The methods comprise screening molecules for their capacity to modulate the HSD17B family member protein, including inhibiting the HSD17B family member protein, as measured by substrate depletion, product concentration from the HSD17B family member protein substrate conversion or NADH concentration, levels of labeled substrate, luciferin light emission, or combinations thereof. Inhibitors of HSD17B family member proteins identified through the screening methods may be used to treat liver diseases, disorders, or conditions in which the HSD17B family member protein plays a role.

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Patent Owner(s)

Patent OwnerAddress
REGENERON PHARMACEUTICALS INC777 OLD SAW MILL RIVER ROAD TARRYTOWN NY 10591

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Esopi, David Tarrytown, US 2 0
Gromada, Jesper Tarrytown, US 70 170
Haller, Jorge Tarrytown, US 3 0
Liu, Yashu Tarrytown, US 14 63
Murphy, Andrew Tarrytown, US 103 843
Olson, William Tarrytown, US 76 856
Stevis, Panayiotis Tarrytown, US 22 79

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