Method of Identification of Combinatorial Enzymatic Reaction Targets in Glioblastoma Specific Metabolic Network
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United States of America Patent
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Dec 27, 2018
app pub date -
Nov 30, 2016
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Nov 30, 2016
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Abstract
The present invention relates to an in-silico method for identification of enzymatic reaction targets and combinations thereof useful in cancer therapy. Further, the present invention relates to combinatorial targeting of essential metabolites and reactions associated with glioblastoma survival. The present invention provides a way to prevent or treat glioblastoma by regulating/inhibiting a combination of glycine transporter along with one or more enzymes catalyzing the internal glycine serine metabolism.
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