ANTI-TREM2 ANTIBODIES AND METHODS OF USE THEREOF
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United States of America Patent
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Jan 10, 2019
app pub date -
Sep 21, 2018
filing date -
Sep 21, 2018
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Abstract
The invention is generally directed to methods and compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 and/or human TREM2. The methods provided herein find use in preventing, reducing risk, or treating an individual having dementia, frontotemporal dementia, Alzheimer's disease, Nasu-Hakola disease, or multiple sclerosis.
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