Glucose responsive insulin delivery compositions and methods

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 10946102
APP PUB NO 20190015515A1
SERIAL NO

16070223

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Abstract

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Disclosed herein is a glucose-responsive insulin delivery system based on the interaction between the glucose-modified insulin and glucose transporters (GLUTs) on erythrocytes (or red blood cells, RBCs). After being conjugated with glucose, insulin can efficiently bind to RBC membranes. The binding is reversible in the setting of hyperglycemia, resulting in fast release of insulin and subsequent drop of blood glucose (BG) level in vivo. In some embodiments, the delivery vehicle can include: 1) intravenously injectable polymeric nanoparticles (˜100 nm in diameter) coated with RBC membrane and loaded with glucose-modified insulin and/or 2) painless microneedle (MN) patches loaded with the complex of GLUT and glucose-modified insulin.

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Patent Owner(s)

  • NORTH CAROLINA STATE UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gu, Zhen Raleigh, US 82 80
Wang, Chao Raleigh, US 798 2548

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