Antibodies that potently neutralize hepatitis B virus and uses thereof

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United States of America Patent

PATENT NO 10683344
APP PUB NO 20190016785A1
SERIAL NO

15766703

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Abstract

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The present invention relates to antibodies, and antigen binding fragments thereof that bind to the antigenic loop region of hepatitis B surface antigen (HBsAg) and potently neutralize infection of both hepatitis B virus (HBV) and hepatitis delta virus (HDV). The invention also relates to epitopes to which the antibodies and antigen binding fragments bind, as well as to nucleic acids that encode and cells that produce such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments of the invention in the diagnosis, prophylaxis and treatment of hepatitis B and hepatitis D.

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Patent Owner(s)

Patent OwnerAddress
HUMABS BIOMED SABELLINZONA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Corti, Davide Bellinzona, CH 70 81

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