IN VITRO SKIN IMMUNE SYSTEM SIMULATION SYSTEM
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United States of America Patent
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Jan 17, 2019
app pub date -
Sep 4, 2015
filing date -
Sep 4, 2015
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Abstract
The present invention relates to a micro-fluid chip for blood vessel formation. The micro-fluid chip of the present invention is constituted by first to fifth channels arranged adjacent to one another on a substrate in sequence, and two or more micro-structures or micro-posts having a gap therebetween are disposed on the interface that each channel forms together with an adjacent channel while contacting the same. Each channel performs a fluidic interaction with a different channel through the gap formed by the micro-structures, and biochemical materials can move therethrough. The micro-fluid chip, according to the present invention, provides a micro-blood vessel having a flat and continuous blood vessel interface outside a body. Furthermore, cancer angiogenesis, cancer intravasation, and cancer extravasation can be modeled using the micro-fluid chip of the present invention. In addition, the micro-fluid chip of the present invention can be used to screen candidate anti-cancer drugs.
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