In silico process for selecting protein formulation excipients
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United States of America Patent
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Nov 29, 2022
Grant Date -
Feb 28, 2019
app pub date -
Mar 6, 2017
filing date -
Mar 11, 2016
priority date (Note) -
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Abstract
The invention relates to an in silico screening method to identify candidate excipients for reducing aggregation of a protein in a formulation. The method combines computational molecular modeling and molecular dynamics simulations to identify sites on a protein where non-specific self-interaction and interaction of different test excipients may occur, determine the relative binding energies of such interactions, and select one or more test excipients that meet specified interaction criteria for use as candidate excipients in empirical screening studies.
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