Methods of treating cancer

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United States of America Patent

PATENT NO 10912776
APP PUB NO 20190076433A1
SERIAL NO

16065012

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Provided herein are, inter alia, methods of treating cancer by administering to a subject a therapeutically effective amount of an adenosine-A2A(A2A) receptor antagonist or a combination of an adenosine-A2A(A2A) receptor antagonist and a programmed cell death protein 1(PD-1) signaling pathway inhibitor. Further provided are pharmaceutical compositions including an A2A receptor antagonist, a PD-1 signaling pathway inhibitor and a pharmaceutically acceptable excipient. Further provided are methods of detecting cellular effects, for example expression of pCREB, before, after or during adenosine receptor antagonist treatment.

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Patent Owner(s)

  • CORVUS PHARMACEUTICALS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ho, Po Y Burlingame, US 2 6
Hotson, Andrew Burlingame, US 11 6
McCaffery, Ian Oakland, US 25 127
Miller, Richard A Portola Valley, US 96 1938
Willingham, Stephen Sunnyvale, US 21 57

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