ENHANCED ORGANOID FORMATION AND INTESTINAL STEM CELL RENEWAL
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United States of America Patent
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Mar 14, 2019
app pub date -
Mar 13, 2017
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Mar 13, 2017
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Abstract
High mobility group A1 (Hmga1) chromatin remodeling proteins are enriched in intestinal stem cells (ISCs), although their function in this setting was unknown. The present invention describes a method of producing a genetically modified organoid comprising the following steps: isolating a crypt of the small intestine; culturing a portion of the crypt in a culture medium; forming an organoid; and transducing the organoid with a vector comprising Hmga1. Methods using genetically modified organoids to treat or prevent injuries including cancer are described.
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