Massive parallel method for decoding DNA and RNA

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United States of America Patent

PATENT NO 10648028
APP PUB NO 20190085016A1
SERIAL NO

16200549

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Abstract

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This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.

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Patent Owner(s)

Patent OwnerAddress
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK412 LOW MEMORIAL LIBRARY 535 WEST 116TH STREET MAIL CODE 4308 NEW YORK NY 10027

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Edwards, John Robert St. Louis, US 32 2114
Itagaki, Yasuhiro New York, US 32 1862
Ju, Jingyue Englewood Cliffs, US 133 7472
Li, Zengmin Flushing, US 59 3088

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