Isosulfan blue, its crystalline form and process for preparation thereof

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United States of America Patent

PATENT NO 10723745
APP PUB NO 20190225626A1
SERIAL NO

16315270

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Abstract

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Provided is an improved process for the preparation N-[4-[[4-(diethyl amino) phenyl](2,5-disulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-N-ethylethanaminium inner salt sodium salt (Isosulfan blue) of formula I. It also relates to highly pure novel crystalline form of Isosulfan blue hydrate and its process for the preparation thereof. It also relates to an improved process for the preparation of Isosulfan blue sodium hydrate having not more than 0.2% of desethyl impurity of formula A.

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Patent Owner(s)

Patent OwnerAddress
BIOPHORE INDIA PHARMACEUTICALS PVT LTDJUBILEE HILLS HYDERABAD 500033

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Choppari, Sadashiv Hyderabad, IN 1 0
Namana, Suresh Babu Hyderabad, IN 5 0
Nanda, Kumar Mecheril Valsan Hyderabad, IN 7 3
Pitta, Bhaskar Reddy Hyderabad, IN 16 9
Pullagurla, Manik Reddy Hyderabad, IN 39 20
Rangisetty, Jagadeesh Babu Hyderabad, IN 42 46

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