Crystalline pharmaceutical co-crystals of glycopyrronium bromide with lactose

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United States of America Patent

PATENT NO 10662152
APP PUB NO 20190256463A1
SERIAL NO

16307383

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Abstract

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The present invention provides co-crystals of glycopyrronium bromide with lactose. The glycopyrronium bromide and lactose in the novel co-crystals are present in a stoichiometric ratio of from about 1:2 to 2:1. These are characterized by XRD and DSC. Processes for preparing the novel co-crystals are also provided. The co-crystals are also disclosed for use as a medicament, in particular, for treatment of respiratory complaints, such as chronic pulmonary obstructive disease (COPD), bronchitis and asthma. Pharmaceutical compositions comprising the co-crystals as active ingredient are also presented.

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Patent Owner(s)

Patent OwnerAddress
HOVIONE SCIENTIA LIMITEDLOUGHBEG RINGASKIDDY CO CORK IRELAND

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fonseca, Tiago Loures, PT 2 13
Mendes, Zita Lisbon, PT 12 64

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