SONOPHORE-LABELED PROBES AND RELATED IN VIVO IMAGING TECHNIQUES
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United States of America Patent
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Issued Date -
Sep 12, 2019
app pub date -
Nov 10, 2017
filing date -
Nov 11, 2016
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Abstract
The present technology provides compositions and nanoemulsions useful in optoacoustic imaging. A composition of the present technology includes at least one contrast agent covalently linked to a targeting agent; where the at least one contrast agent includes a dark quencher; the targeting agent includes an antibody, an antigen, an antigen-targeting ligand, a receptor ligand, or an adhesion peptide; and the at least one contrast agent and targeting agent are covalently linked by a linker of formula (I) X1-L1-X2 (I) where X1 is an amino, amide, S, or O of the at least one contrast agent; L1 is C1-C12 alkylene, C2-C12 alkenylene, C5-C12 cycloalkylene, or C6-C12 arylene; and X2 is an amino, amide, S, or O of the targeting agent.
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