Importance

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Abstract

A method for online sampling an aliquot from a mobile phase comprising an analyte of an apparatus (102) for producing a pharmaceutical or chemical product, wherein the apparatus (102) comprises an analytical device (114) and a tube (112), wherein the tube (112) comprises an inlet (116), an outlet (118) and at least one curved portion (120), wherein the outlet (118) is in fluid communication with the analytical device (114), wherein the curved portion (120) is located between the inlet (116) and the outlet (118), wherein a flow direction of the mobile phase is defined from the inlet (116) to the outlet (118), the method comprising: providing a sample device (124) comprising a needle (134) with a needle tip (136), a septum (138) pierceable by the needle (134) and a pump (128), wherein the needle (134) is moveable between an extended position in which the septum (138) is pierced by the needle (134), and a retracted position, in which the septum (138) is not pierced, disposing the sample device (124) at the curved portion (120) of the tube (112), moving the needle (134) to the extended position such that the needle tip (136) faces the flow direction, and operating the pump (128) so as to draw an aliquot out of the mobile phase.

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First Claim