Transcription modulation in animals using CRISPR/Cas systems

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United States of America Patent

PATENT NO 11519004
APP PUB NO 20190284572A1
SERIAL NO

16358395

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Abstract

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Non-human animal cells and non-human animals comprising CRISPR/Cas synergistic activation mediator system components and methods of making and using such non-human animal cells and non-human animals are provided. Methods are provided for using such non-human animals to increase expression of target genes in vivo and to assess CRISPR/Cas synergistic activation mediator systems for the ability to increase expression of target genes in vivo.

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Patent Owner(s)

  • REGENERAN PHARMACEUTICALS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gong, Guochun Pleasantville, US 29 115
Hartford, Suzanne Putnam Valley, US 15 43
Hunt, Charleen Dumont, US 19 456
Zambrowicz, Brian Sleepy Hollow, US 186 501

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