Nanoparticle transducer sensors and methods of use thereof

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United States of America Patent

PATENT NO 11542539
APP PUB NO 20190284601A1
SERIAL NO

16307363

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Abstract

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The present disclosure provides nanoparticle transducers and methods of use thereof for the detection of analyte concentrations in a fluid. Nanoparticle transducers can comprise a nanoparticle, such as a Pdot, coupled to an enzyme that catalyzes a reaction with the analyte. The nanoparticle transducers further comprise chromophores that emit fluorescence that varies as a function of the concentration of one of the elements of the reaction. The nanoparticle transducer thus changes fluorescence as the analyte concentration changes, transforming analyte concentration values into fluorescence intensities. The measurement of these intensities provides a measurement of the analyte concentration. The nanoparticle transducers are biocompatible, allowing for use in vivo, for the monitoring of analyte blood concentrations such as blood glucose concentrations.

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Patent Owner(s)

  • BOARD OF REAGENTS OF THE UNIVERSITY OF WASHINGTON; LAMPROGEN, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chiu, Daniel T Seattle, US 95 2031
Sun, Kai Changchun, CN 112 556
Wu, Changfeng Changchun, CN 31 270
Yu, Jiangbo Seattle, US 32 223

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