NOVEL ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE

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United States of America Patent

APP PUB NO 20190307818A1
SERIAL NO

16091990

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates to compositions for inhibiting or agonizing quorum sensing (QS) pathways to repress biofilm formation, biofilm streamer formation, virulence factor production, and/or infections (including bacterial infections and bacterial infections with resistance to antibiotics) by: (a) a monotherapy using novel compounds, such as small molecule inhibitors or agonists, to inhibit or activate QS activation pathways and/or (b) a combination therapy including novel compounds to inhibit or activate QS and/or to sensitize bacteria to phage along with phage therapy. These compositions can be used to treat patients having infections. Additionally, these compositions can be used to treat surfaces/areas known to contain human pathogens notorious for causing hospital-acquired infections (such as intravenous catheters, implants, medical devices) as well as fatal infections that occur outside of health care settings. Preferred microorganisms that can be treated with the compositions of the invention include, but are not limited to bacterial strains resistant to one or more antibiotics.

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Patent Owner(s)

Patent OwnerAddress
THE TRUSTEES OF PRINCETON UNIVERSITY619 ALEXANDER RD SUITE 102 PRINCETON NJ 08540

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bassler, Bonnie L Princeton, US 37 194
Hoyland-Kroghsbo, Nina M Copenhagen, DK 1 1
Paczkowski, Jon E Princeton, US 1 1

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