Benzo[b]thiophene compounds as STING agonists

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United States of America Patent

PATENT NO 10703738
APP PUB NO 20190337917A1
SERIAL NO

16513409

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Abstract

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Compounds of general formula (Ia), compounds of general formula (Ia′), compounds of general formula (Ib), compounds of general formula (Ib′), compounds of general formula (I), compounds of general formula (I′), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, R6, R8, R9, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.

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Patent Owner(s)

Patent OwnerAddress
MERCK SHARP & DOHME LLC126 EAST LINCOLN AVENUE RAHWAY NJ 07065

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Altman, Michael D Needham, US 65 690
Cash, Brandon D Stoughton, US 6 19
Chang, Wonsuk Princeton, US 40 609
Cumming, Jared N Winchester, US 88 817
Haidle, Andrew M Somerville, US 21 248
Henderson, Timothy J Natick, US 21 81
Jewell, James P Newton, US 22 209
Larsen, Matthew A Dedham, US 13 20
Liang, Rui New Brunswick, US 60 740
Lim, Jongwon Lexington, US 54 435
Lu, Min Brookline, US 133 1408
Otte, Ryan D Natick, US 31 286
Siu, Tony Brookline, US 29 242
Trotter, Benjamin Wesley Medfield, US 22 138
Tyagarajan, Sriram Edison, US 17 68

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