BIOMEDICAL PATCHES WITH ALIGNED FIBERS

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United States of America

SERIAL NO

16540548

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Abstract

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A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.

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Patent Owner(s)

Patent OwnerAddress
WASHINGTON UNIVERSITYONE BROOKINGS DRIVE ST LOUIS MISSOURI 63130 UNITED STATES OF AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
MacEwan, Matthew R St. Louis, US 14 13
Ray, Zack St. Louis, US 5 8
Xia, Younan St. Louis, US 46 1627
Xie, Jingwei St. Louis, US 14 15

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