GUT MICROBIOTA AND TREATMENT OF CANCER

Number of patents in Portfolio can not be more than 2000

United States of America

SERIAL NO

16461850

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Abstract

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The ubiquitin ligase, RNF5, regulates the gut microbiota composition and influences the immune checkpoint response to tumors. RNF5 deficient animals exhibit significant inhibition of tumor development as well as an altered gut microbiota composition. Methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species are disclosed. Also disclosed are methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species in combination with one or more anti-cancer agents.

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Patent Owner(s)

Patent OwnerAddress
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTNot Provided

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ashkenazi, Shiri Haifa, IL 1 0
Bradley, Linda La Jolla, US 3 11
Li, Yan La Jolla, US 795 13158
Peterson, Scott La Jolla, US 51 313
Ronai, Ze`ev La Jolla, US 1 0
Tinoco, Roberto La Jolla, US 2 0

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