Method for Constructing PD-1 Gene Modified Humanized Animal Model and Use Thereof

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United States of America

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16313819

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Provided is a method for preparing a PD-1 gene-modified humanized animal model. The method utilizes the CRIPSR/Cas9 technique to replace partial fragments of a mouse PD-1 gene with fragments of a human PD-1 gene using homologous recombination by constructing a targeting vector, thereby preparing a gene-modified humanized mouse. This mouse can normally express a PD-1 protein containing the functional domain of the human PD-1 protein, and can be used as an animal model for mechanism research regarding PD-1, PD-L1 and other signals, for screening regulators, and for toxicological research. The method has an important and high application value in studies on functions of the PD-1 gene and in the development of new drugs.

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BEIJING BIOCYTOGEN CO LTD88 KECHUANG 6TH AVE BDA BUILDING 3 RM 1207 YIZHUANG BEIJING 101111

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bai, Yang Beijing, CN 80 773
Du, Jichao Beijing, CN 2 0
Guo, Yanan Beijing, CN 24 1
Hu, Yuting Beijing, CN 2 0
Huang, Rui Beijing, CN 211 2207
Shen, Yuelei Beijing, CN 24 1
Zhou, Xiaofei Beijing, CN 14 7

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