NEURON-SPECIFIC HuR-DEFICIENT OR INDUCIBLE HuR-DEFICIENT ANIMAL MODELS

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United States of America

APP PUB NO 20200015461A1
SERIAL NO

16446274

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Provided herein non-human transgenic animals comprising a genome that: i) under-expresses, or is inducible to under-express, Hu Antigen R (HuR) in at least some neurons of said transgenic animal; ii) does not express HuR, or is inducible to not express HuR, in at least some neurons of said transgenic animal; or iii) does not express functional HuR, or is inducible to not express functional HuR in at least some neurons of said transgenic animal, as well as methods of screening drugs and therapies (e.g., useful in treating ALS) using such animals.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Xing Cleveland, US 122 2734
Herjan, Tomasz Beachwood, US 1 0
Li, Xiaoxia Cleveland, US 16 12
Sun, Kevin Solon, US 4 54

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