METHOD OF MEASURING EFFICACY OF TREATMENT FOR AN AUTOIMMUNE DISEASE IN VIVARIUM ANIMALS

Number of patents in Portfolio can not be more than 2000

United States of America

APP PUB NO 20200015741A1
SERIAL NO

16578298

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Abstract

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A method of measuring efficacy of test treatment of an autoimmune disease in an animal in a vivarium is described. Animal activity data is collected at multiple times during the night. Sequential time regions of the night are identified as high-activity, activity-drop, or low-activity regions. Embodiments are described to quantify a drop, during the night, of an animal's activity level. These quantified activity-drop scalars for consecutive nights are accumulated in an animal health dataset. This dataset is compared to healthy animals, a standard of care or a reference treatment for the first disease to determine efficacy of the test treatment. One embodiment quantifies an activity-drop by fitting straight-line curves through the data in the three nightly regions. Other embodiment uses a Fourier transform on a circle, LASSO, RANSAC or regression analyses for curve fitting. Another embodiment compares areas under data curves in the regions. Animals may be housed in cages with other animals.

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Patent Owner(s)

  • VIUM, INC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ford, Daniel J Belmont, US 14 14
Schaevitz, Laura Los Gatos, US 22 9

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