HUMAN CYTOMEGALOVIRUS NEUTRALIZING ANTIBODIES AND USE THEREOF

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United States of America

APP PUB NO 20200017575A1
SERIAL NO

16527836

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Abstract

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The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hCMV gene UL products. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, prevention, and therapy of disease.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
LANZAVECCHIA, Antonio Bellinzona, CH 61 720
MACAGNO, Annalisa Bellinzona, CH 38 574

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