NOVEL ANTI-TRKB ANTIBODIES

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United States of America

APP PUB NO 20200017590A1
SERIAL NO

16492954

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Abstract

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Provided is an isolated TrkB agonist antibody that binds to an epitope contained in one of the extracellular domains of TrkB and is capable of activating TrkB, wherein the extracellular domains comprises extracellular D1, D2, D3, D4, D5 domains and juxtamembrane domain of TrkB. Methods of using the TrkB agonist antibody in treating or reducing the risk of a TrkB associated conditions in a subject, wherein said condition is selected from cell differentiation, synaptic development, neural injury repairing and/or neurite branching.

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Patent Owner(s)

Patent OwnerAddress
TSINGHUA UNIVERSITYBEIJING 100084

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
GUO, Wei Beijing, CN 320 2444
LU, Bai Beijing, CN 8 11
YAO, Hongyang Beijing, CN 5 1

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