ALTERATION OF TOBACCO ALKALOID CONTENT THROUGH MODIFICATION OF SPECIFIC CYTOCHROME P450 GENES

Number of patents in Portfolio can not be more than 2000

United States of America

APP PUB NO 20200022326A1
SERIAL NO

16511596

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Abstract

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Compositions and methods for reducing the level of nornicotine and N′-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome P450s that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Expression cassettes, vectors, plants, and plant parts thereof comprising inhibitory sequences that target expression or function of the disclosed cytochrome P450 polypeptides are also provided. Methods for the use of these novel sequences to inhibit expression or function of cytochrome P450 polypeptides involved in this metabolic conversion are also provided. The methods find use in the production of tobacco products that have reduced levels of nornicotine and its carcinogenic metabolite, NNN, and thus reduced carcinogenic potential for individuals consuming these tobacco products or exposed to secondary smoke derived from these products.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION201 GILLIS BUILDING LEXINGTON KY 40506-0033

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bowen, Steven W Raleigh, US 10 161
Dewey, Ralph E Apex, US 28 191
Gavilano, Lily Raleigh, US 10 161
Siminszky, Balazs Neuchatel, CH 12 170

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