METHODS AND COMPOSITIONS COMPRISING A NITRITE-REDUCTASE PROMOTER FOR TREATMENT OF MEDICAL DISORDERS AND PRESERVATION OF BLOOD PRODUCTS

Number of patents in Portfolio can not be more than 2000

United States of America

APP PUB NO 20200022952A1
SERIAL NO

16284035

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Abstract

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The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and preservation of blood products. In one aspect, the invention provides methods, compositions, and medical kits comprising an inorganic nitrite salt and a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders, such as cancer, cardiovascular disorders, ischemic conditions, hemolytic conditions, and bacterial infections. Exemplary inorganic nitrite salts include sodium nitrite and arginine nitrite. Exemplary allosteric modulators of hemoglobin described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brouse, Chad San Diego, US 2 3
Cabrales, Pedro San Diego, US 12 22
Fens, Marcel San Francisco, US 2 3
Fitch, William Palo Alto, US 4 94
Knox, Susan Stanford, US 14 83
Kuypers, Frans A El Cerrito, US 7 18
Larkin, Sandra Berkeley, US 2 3
Oronsky, Bryan T Los Altos Hills, US 36 373
Scicinski, Jan Saratoga, US 11 40

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