METHODS FOR GENERATING AND SCREENING COMPARTMENTALISED PEPTIDE LIBRARIES

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United States of America

APP PUB NO 20200049695A1
SERIAL NO

16487478

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Abstract

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A method for co-compartmentalising a cyclic polypeptide with a polynucleotide encoding the cyclic polypeptide, comprising the steps of a) forming a compartment containing a polynucleotide encoding the cyclic polypeptide, b) expressing a polypeptide from the polynucleotide, and c) cyclising the polypeptide. Co-compartmentalised cyclic polypeptides and encoding polynucleotides. Libraries of co-compartmentalised cyclic polypeptide and encoding polynucleotide. Methods for screening libraries of co-compartmentalised cyclic polypeptide and encoding polynucleotide. Incorporation of non-canonical nucleic acids into such libraries.

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Patent Owner(s)

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UNIVERSITY OF SOUTHAMPTONSOUTHAMPTON HAMPSHIRE SO17 1BJ

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
FISCHLECHNER, Martin Wien, AT 4 3
SOHRABI, Catrin West Drayton, London, GB 1 0
TAVASSOLI, Ali Southampton, Hamsphire, GB 5 2

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