METHODS FOR TISSUE PASSIVATION
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United States of America
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Issued Date -
Mar 12, 2020
app pub date -
Nov 18, 2019
filing date -
Nov 18, 2019
priority date (Note) -
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Abstract
One aspect of the invention provides a method of preventing or reducing stenosis in a subject. The method includes implanting a passivated graft comprising vein into an artery. The implanting of the graft replaces and/or bypasses a diseased segment of the artery. The passivated graft including vein is prepared by exposing the exterior surface of the passivated graft comprising vein to a tissue structure stabilizing agent (“TSSA”) under conditions sufficient to promote cross-linking of proteins within the vein.
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