AN ENGINEERED MULTI-COMPONENT SYSTEM FOR IDENTIFICATION AND CHARACTERISATION OF T-CELL RECEPTORS, T-CELL ANTIGENS AND THEIR FUNCTIONAL INTERACTION

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United States of America

APP PUB NO 20200095574A1
SERIAL NO

16347691

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Abstract

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The present invention relates to a multicomponent system wherein a first component is an engineered TCR-presenting cell (eTPC), designated component A, wherein component A lacks endogenous surface expression of at least one family of analyte antigen-presenting complexes (aAPX) and/or analyte antigenic molecule (aAM), and a second component is a genetic donor vector, designated component C, for delivery of ORF encoding analyte TCR chains.

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Patent Owner(s)

Patent OwnerAddress
GENOVIE AB151 36 SÖDERTÄLJE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
HILL, Ryan Edward Karlskrona, SE 11 17
Jarvis, Reagan Micheal Karlskrona, SE 13 12
PASE, Luke Benjamin Karlskrona, SE 8 6

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