Sprayable barrier and methods for prevention of postoperative adhesions

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United States of America Patent

PATENT NO 11623029
APP PUB NO 20200101203A1
SERIAL NO

16500556

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Abstract

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Biologically acceptable surgical barrier materials are comprised of a polyelectrolytic complex of chitosan and sodium alginate. The chitosan is deacetylated in an amount between about 40 to about 60% and has a molecular weight (Mw) between 50,000 and 375,000 g/mol. The barrier materials may be formed by mixing a two-component material system whereby one component comprises the chitosan and a second component comprises the sodium alginate and directing such a mixture (e.g., via air-assisted spray nozzle) toward a surgical site in need of the material. A polyelectrolytic complex of the chitosan and sodium alginate will thereby form in situ. Suitable ionic cross-linkers may be provided in the individual components, e.g., calcium chloride with the chitosan component and sodium tripolyphosphate with the sodium alginate component.

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Patent Owner(s)

Patent OwnerAddress
LUNA LABS USA LLC706 FOREST STREET SUITE A CHARLOTTESVILLE VA 22903

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Costella, Lauren Anne Roanoke, US 3 0
Cottler, Patrick Roanoke, US 1 0
Danilich, Michael J Roanoke, US 5 61
Tison, Christopher K Roanoke, US 4 1

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