Methods and compositions for identifying epitopes

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11834653
APP PUB NO 20200102553A1
SERIAL NO

16619859

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Described herein, in one aspect, are antigen presenting cells (APCs) comprising an exogenous nucleic acid encoding one or more candidate antigens, wherein the one or more candidate antigens are expressed and presented with MHC class I or MC class II molecules; a molecular reporter of Granzyme B (GzB) activity; and c) an exogenous inhibitor of caspase-activated deoxyribonuclease (CAD)-mediated DNA degradation, a CAD knockout, or a caspase knockout (e.g., caspase 3 knockout). Described herein, in another aspect, is a system for detection of recognized antigen presentation by an antigen presenting cell to a cytotoxic lymphocyte or NK cell.

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Patent Owner(s)

  • THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dezfulian, Mohammad Haj Boston, US 1 0
Elledge, Stephen Brookline, US 6 28
Kula, Tomasz Brookline, US 11 5

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